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desvenlafaxine will increase the degree or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Warning/Check. Desvenlafaxine inhibits CYP2D6; with bigger desvenlafaxine doses (ie, four hundred mg) lower the CYP2D6 substrate dose by as many as 50%; no dosage adjustment needed with desvenlafaxine doses seven consecutive days instantl